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It has been identified in one veterinary report of three cavalier King Charles spaniels. Dogs have natural occuring antibodies against the DEA 1 antigen in red blood cells (erythrocytes or RBCs).In a dog with DEA 1 negative RBCs and with an immune system which is highly sensitized to DEA 1 positive RBCs, the system will produce alloantibodies following the first transfusion of DEA 1 positive blood.In a November 2016 article, a team of Wisconsin and Michigan researchers studied the clinical records of 79 dogs diagnosed with immune-mediated polyarthritis (IMPA).

However, it is more common in cavalier King Charles spaniels, as these veterinary reports indicate.

This evidence indicates the CKCS may have a genetic predisposition to this disorder and probable weakness in the femoral artery wall.

Results indicated erosive IMPA most commonly affected the carpal joints of middle-aged small-breed dogs.

Bell's palsy is an idiopathic facial nerve paralysis, which occurs without evidence of infection, reduced thryroid function, or injury. In a September 2017 article by a team of Italian veterinary blood specialists, they studied 7,414 dogs, including 103 cavalier King Charles spaniels, to determine the potential sensitization risk to dogs receiving blood transfusions consisting of the Dog Erythrocyte Antigen (DEA) 1 blood group.

They therefore recommend: "Blood typing to identify the presence of DEA 1 and the cross-match to establish full compatibility should be performed before each transfusion in order to reduce the risk of sensitization or immunological reaction between donor and recipient dogs." antibodies in response to exposure to allergens that areinhaled or absorbed through the skin.

Malassezia dermatitis consists ofyeast infections, for which the CKCS has been found to be at increased risk.

The most frequently affected breeds were: (1) golden retriever, (2) Labrador retriever, (3) Rottweiler, (4) German shepherd, and (5) border collie.

The overall average of all dogs diagnosed with osteoarthritis was 2.5%.

Arthritis usually is a progressive degeneration of what are known as synovial joints, which are joints with a capsule filled with synovial fluid which surrounds the bones' surfaces.

The degeneration leads to impaired function and pain.

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